an AGC kinase that plays a critical role in controlling the balance between survival and apoptosis. Phosphorylated and activated by PDK1 in the PI3 kinase pathway. Mediates survival signals downstream of PI3 kinase and several growth factor receptors by phosphorylating apopototic proteins. First found in a mouse transforming retrovirus. Tumorigenic in a mouse lymphoma model and activated (by phospho-Akt staining) and/or overexpressed in a number of cancers including breast, prostate, lung, pancreatic, liver, ovarian and colorectal. Inhibitor: RX-0201. Substrates include tuberin, Bad, Forkhead transcription factors, caspase-9, and glycogen synthase kinase-3.
Anti-AKT (Phospho S473) Rabbit mAb
Catalog number :AT0542
- Overview
- Description
- Phospho-Akt(Ser473) Rabbit monoclonal Antibody
- Reactivity
- Human, Mouse, Rat
Phospho-Akt(Ser473) Antibody detects endogenous levels of Akt only when phosphorylated at Sersine 473
- Tested applications
- WB 1:500-1:2000 IHC 1:50-1:200 IF/ICC 1:100-1:500
- Properties
- Immunogen
- A synthesized peptide derived from human Akt around the phosphorylation site of Sersine 473
- Clonality
- Monoclonal, clone number: 5DG7
- Isotype
- Rabbit IgG
- Form
Fluid containing 0.03% sodium azide.
- Storage instruction
- Store at -20 °C.Stable for 12 months from date of receipt
- Database links
Swiss Prot：P31749
- Applications
- WB Image
Mol Weight： 60kDa
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