Anti-Androgen Receptor Rabbit mAb
Catalog number :AT0462
Androgen receptor (AR), a zinc finger transcription factor belonging to the nuclear receptor superfamily, is activated by phosphorylation and dimerization upon ligand binding. This promotes nuclear localization and binding of AR to androgen response elements in androgen target genes. Research studies have shown that AR plays a crucial role in several stages of male development and the progression of prostate cancer.
- Overview
- Reactivity
- Mouse, Rat, Human
- Tested applications
- Western Blot: 1:1000Immunohistochemistry: 1:100Immunofluorescence: 1:100
- Specificity
- Detects endogenous levels of total androgen receptor protein.
- Properties
- Immunogen
- Produced by immunizing animals with recombinant protein corresponding to residues near the amino terminal region of human androgen receptor protein.
- Clonality
- Monoclonal, clone number: 4HC3
- Isotype
- Rabbit IgG
- Storage instruction
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C
- Applications
- WB Image
Western blot analysis of extracts from LNCaP (AR+), MCF7 (AR+), PC-3 (AR-), and DU 145 (AR-) cells using Androgen Receptor
- ICC/IF Image
Immunocytochemistry/Immunofluorescence: Androgen R Antibody - Staining of human cell line U-2 OS shows localization to mitochondria.
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