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    Anti-Beclin 1 Rabbit mAb

    Catalog number :AT1792
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    Autophagy is a catabolic process for the autophagosomic-lysosomal degradation of proteins activated in response to nutrient deprivation and in neurodegenerative conditions. One of the proteins critical to this process is Beclin-1, the mammalian orthologue of the yeast autophagy protein Apg6/Vps30. Beclin-1 can complement defects in yeast autophagy caused by loss of Apg6 and can also stimulate autophagy when overexpressed in mammalian cells. Mammalian Beclin-1 was originally isolated in a yeast two-hybrid screen for Bcl-2 interacting proteins and has been shown to interact with Bcl-2 and Bcl-xL, but not with Bax or Bak. While Beclin-1 is generally ubiquitously expressed, research studies have shown it is monoallelically deleted in 40-75% of sporadic human breast and ovarian cancers. Beclin-1 is localized within cytoplasmic structures including the mitochondria, although overexpression of Beclin-1 reveals some nuclear staining and CRM1-dependent nuclear export. Investigators have demonstrated that Beclin-1-/- mice die early in embryogenesis and Beclin-1-/+ mice have a high incidence of spontaneous tumors. Stem cells from the null mice demonstrate an altered autophagic response, although responses to apoptosis appeared normal. Researchers have also found that overexpression of Beclin-1 in virally infected neurons in vivo resulted in significant protection against Sindbis virus-induced disease and neuronal apoptosis.
    Swiss-Prot Acc: Q14457
    Overview
    Reactivity
    Mouse, Rat, Human
    Tested applications
    Western Blot: 1:1000
    Immunohistochemistry: 1:500
    Immunoprecipitation: 1:100
    Specificity
    Recognizes endogenous levels of total Beclin-1 protein.
    Properties
    Immunogen
    Produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Thr72 of human Beclin-1.
    Clonality
    Monoclonal, clone number: 5B7
    Isotype
    Rabbit IgG
    Storage instruction
    Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C 
    Applications
    WB Image

    Western Blot: Beclin 1 Antibody - Analysis of Belclin1. Lane 1: human brain. Lane 2: mouse brain.
    ICC/IF Image

    Immunohistochemistry-Frozen: Beclin 1 Antibody - Merged immunostaining of frozen section of Rat brain tissue.

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