Anti-CD105 (Endoglin) Rabbit mAb

Product

Anti-CD105 (Endoglin) Rabbit mAb

Catalog number :AT0706

Endoglin (ENG, CD105) is an auxiliary receptor for the TGF-β receptor complex, functioning in related signaling pathways. Endoglin is a transmembrane protein that exists as a disulfide-linked homodimer. It is mainly expressed in vascular and connective tissues and in endothelial and stromal cells. Upregulated endoglin expression has been reported during wound healing and tumor vascularization, and in inflammatory tissues and developing embryos. Mutations in endoglin have been found to be a causal factor of hereditary hemorrhagic telangiectasia (HHT), a disease characterized by malformation of vascular structure. The importance of this protein for normal and tumor vascular function makes it a good marker for endothelial cell proliferation as well as a potential therapeutic target in cancer.

UniProt ID:

P17813

Overview

Reactivity: Human, mouse, rat, bovine, chicken, Drosophilia melanogaster

Tested applications: Western Blotting 1:1000

Immunofluorescence 1:500

Immunohistochemistry (Paraffin) 1:500

Immunoprecipitation(IP) 1;100

Optimal dilutions/concentrations should be determined by the end user.

Specificity: This antibody detects endogenous levels of total CD105 protein. Recognises the human CD105 cell surface antigen.

Properties

Immunogen: Purified recombinant fragment of human CD105 expressed in E. coli.

Clonality: Monoclonal, clone number: 5FD7

Isotype: Rabbit IgG

Form: Liquid, 100 μl,1mg/ml, PBS (pH 7.2) and 40% Glycerol，0.02% Sodium Azide

Storage instruction: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C, Avoid freeze / thaw cycle.

Host: Rabbit

Applications

WB Image: Western Blot: Endoglin/CD105 Antibody - Whole cell protein from HUVEC was separated on a 7.5% gel polyacrylamide gel and transferred to PVDF membrane. The membrane was probed with anti-CD105 antibody at 1:1000 and detected with an anti-Rabbit HRP labeled secondary antibody using chemiluminescence.

IHC Image: Immunohistochemistry-Paraffin: CD105 Antibody - Immunohistochemical analysis of paraffin-embedded kidney cancer tissues (left) and stomach cancer tissues (right) using CD105 rabbit polyclonal antibody with DAB staining.

ICC/IF Image: Immunocytochemistry/Immunofluorescence: Endoglin/CD105 Antibody - HMSC cells stained with anti-CD105 antibody.

Anti-CD105 (Endoglin) Rabbit mAb

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