Anti-CD90/Thy1 Rabbit mAb

Product

Anti-CD90/Thy1 Rabbit mAb

Catalog number :AT0637

The Thy1/CD90 cell surface antigen is a GPI-anchored, developmentally regulated protein involved in signaling cascades that mediate neurite outgrowth, T cell activation, tumor suppression, apoptosis, and fibrosis. Thy1/CD90 is highly expressed on the surface of adult neurons and is thought to play a role in modulating adhesive and migratory events, such as neurite extension. Decreased Thy1/CD90 mRNA and protein expression is associated with the development of epithelial ovarian cancer, suggesting a role as a putative tumor suppressor gene of human ovarian cancer. Research studies indicate that Thy1/CD90 knockout mice have impaired cutaneous immune responses and abnormal retinal development. Thy1/CD90 is epigenetically regulated or deregulated in some disease states, such as pulmonary fibrosis. The potentially reversible hypermethylation of the Thy1/CD90 promoter offers the possibility of novel therapeutic options in this disease.

Overview

Reactivity: Mouse, Rat, Human

Tested applications: Western Blotting 1:1000

Immunoprecipitation 1:50

Immunohistochemistry (Paraffin) 1:500

Specificity: This antibody recognizes endogenous levels of total Thy1/CD90 protein.

Properties

Immunogen: Full length protein corresponding to Rat CD90/ Thy1.

Clonality: Monoclonal, clone number: 5HR7

Isotype: Rabbit IgG

Form: Liquid, 100 μl,1mg/ml

Storage instruction: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C

Host: Rabbit

Applications

WB Image: Western Blot: CD90/Thy1 Antibody - Analysis of THY1 on different lysates using anti-THY1 antibody at 1/1,000 dilution.

Lane 1: Hela Lane 2: HepG2 Lane 3: HUVEC

IHC Image: Immunohistochemistry-Paraffin: CD90/Thy1 Antibody - Analysis of paraffin-embedded human tonsil tissue using anti-THY1 antibody. Counter stained with hematoxylin.

ICC/IF Image: Immunocytochemistry/Immunofluorescence: CD90/Thy1 Antibody - Staining THY1 in PC-12 cells (red).

The nuclear counter stain is DAPI (blue).

Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Anti-CD90/Thy1 Rabbit mAb

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