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    Anti-Caveolin-1 Rabbit mAb - Caveolae Marker

    Catalog number :AT1605
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    Background: 
    The 21-24 kDa integral proteins, caveolins, are the principal structural components of the cholesterol/sphingolipid-enriched plasma membrane microdomain caveolae. Three members of the caveolin family (caveolin-1, -2, and -3) have been identified with different tissue distributions. Caveolins form hetero- and homo-oligomers that interact with cholesterol and other lipids. Caveolins are involved in diverse biological functions, including vesicular trafficking, cholesterol homeostasis, cell adhesion, and apoptosis, and are also implicated in neurodegenerative disease. Caveolins interact with multiple signaling molecules such as Gα subunit, tyrosine kinase receptors, PKCs, Src family tyrosine kinases, and eNOS. It is believed that caveolins serve as scaffolding proteins for the integration of signal transduction. Phosphorylation at Tyr14 is essential for caveolin association with SH2 or PTB domain-containing adaptor proteins such as GRB7. Phosphorylation at Ser80 regulates caveolin binding to the ER membrane and entry into the secretory pathway.
     
    UniProt ID: Q03135
    Overview
    Reactivity
    Human, Mouse, Rat, Bovine, Pig, Monkey
    Tested applications
    Western Blotting: 1/1000-1/2000
    Immunofluorescence: 1/500
    Immunohistochemistry (Paraffin): 1/500
    Immunoprecipitation(IP) : 1/100 
    Optimal dilutions/concentrations should be determined by the end user. 
    Specificity
    This antibody detects endogenous levels of total Caveolin-1 protein. 
    Properties
    Immunogen
    a synthetic peptide corresponding to residues surrounding Glu20 of human caveolin-1.
    Clonality
    Monoclonal, clone number: 4GA34
    Isotype
    Rabbit IgG
    Form
    Liquid, 100 μl,1mg/ml, PBS (pH 7.2) and 40% Glycerol,0.02% Sodium Azide
    Storage instruction
    Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C, Avoid freeze / thaw cycle.
    Host
    Rabbit
    Applications
    WB Image

    Western Blot: Caveolin-1 Antibody - Lane 1: Marker [kDa] 250, 130, 100, 70, 55, 35, 25, 15, 10 Lane 2: Human Lung tissue
    IHC Image

    Immunohistochemistry-Paraffin: Caveolin-1 Antibody - Staining of human lung shows high expression.

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