Anti-Cytokeratin 7 Rabbit mAb - Cytoskeleton Marker

Product

Anti-Cytokeratin 7 Rabbit mAb - Cytoskeleton Marker

Catalog number :AT1606

Background:

Keratins (cytokeratins) are intermediate filament proteins that are mainly expressed in epithelial cells. Keratin heterodimers composed of an acidic keratin (or type I keratin, keratins 9 to 23) and a basic keratin (or type II keratin, keratins 1 to 8) assemble to form filaments. Keratin isoforms demonstrate tissue- and differentiation-specific profiles that make them useful as research biomarkers. Research studies have shown that mutations in keratin genes are associated with skin disorders, liver and pancreatic diseases, and inflammatory intestinal diseases.

Keratin 7 and Keratin 19 are present in hepatic and pancreatic progenitor/stem cells.

UniProt ID: P08729

Overview

Reactivity: Human, Mouse, Rat, Bovine, Pig, Monkey

Tested applications: Western Blotting: 1/1000-1/2000

Immunofluorescence: 1/500

Immunohistochemistry (Paraffin): 1/500

Immunoprecipitation(IP) : 1/100

Optimal dilutions/concentrations should be determined by the end user.

Specificity: This antibody detects endogenous levels of total Cytokeratin 7 protein.

Properties

Immunogen: a synthetic peptide corresponding to residues near the carboxy terminus of human keratin 7 protein.

Clonality: Monoclonal, clone number: 5TF7

Isotype: Rabbit IgG

Form: Liquid, 100 μl,1mg/ml, PBS (pH 7.2) and 40% Glycerol，0.02% Sodium Azide

Storage instruction: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C, Avoid freeze / thaw cycle.

Host: Rabbit

Applications

WB Image: Western Blot: Cytokeratin 7 Antibody - Analysis in mouse cell line NIH-3T3 and rat cell line NBT-II.

IHC Image: Immunohistochemistry-Paraffin: Cytokeratin 7 Antibody - Staining of human breast shows strong membranous positivity in glandular cells.

Anti-Cytokeratin 7 Rabbit mAb - Cytoskeleton Marker

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