Endotoxin Removal Agarose Beads (Polymyxin B)

Product

Endotoxin Removal Agarose Beads (Polymyxin B)

Catalog number :IF9245

Polymyxin B is a strongly cationic cyclic antibiotic isolated from Bacillus polymyxa. It inhibits growth of microorganisms, including E. coli. It is a variable mixture of B1 and B2, with approximate molecular weight 1450. Polymyxins combine with cell membranes and disrupt normal permeability to small molecules.

Because of its affinity for bacterial cell membranes (which are lipopolysaccharides, also called endotoxins), Polymyxin B has been immobilized on agarose and used to remove endotoxins from solutions. Histamine agarose has been used for the same purpose.

Overview

Description: Endotoxin Removal Agarose Beads (Polymyxin B Agarose Beads)

Properties

Form: suspension in 50% glycerol containing 0.02% sodium azide

Ligand immobilized	Approximately 1 mg Polymyxin B per mL Beads
Matrix	Highly cross-linked 6% agarose beads
Coupled	Polymyxin B is attached through an amino group, with a 1-atom spacer
Binding capacity	200-500 g lipopolysaccharide from Escherichia coli serotype 0128:B12 per mL beads

Applications

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Endotoxin Removal Agarose Beads (Polymyxin B)

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