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    Anti-Integrin beta 1 Rabbit mAb

    Catalog number :AT0708
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    Integrins are α/β heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival. The integrin family contains at least 18 α and 8 β subunits that form 24 known integrins with distinct tissue distribution and overlapping ligand specificities. Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with the extracellular environment (inside-out signaling).
     
    The β1 subfamily includes 12 distinct integrin proteins that bind to different extracellular matrix molecules. Control of extracellular integrin binding influences cell adhesion and migration, while intracellular signaling messages relayed by the β1 cytoplasmic tail help to regulate cell proliferation, cytoskeletal reorganization, and gene expression. Research studies have implicated β1 integrin in various activities including embryonic development, blood vessel, skin, bone, and muscle formation, as well as tumor metastasis and angiogenesis.
     
    UniProt ID: 
    P05556
     
    Overview
    Reactivity
    Human, mouse, rat, bovine, chicken, Drosophilia melanogaster
    Tested applications
    Western Blotting 1:1000
    Immunofluorescence  1:500
    Immunohistochemistry (Paraffin) 1:500
    Immunoprecipitation(IP)  1;100 
    Optimal dilutions/concentrations should be determined by the end user. 
     
    Specificity
    This antibody detects endogenous levels of total Integrin beta 1 protein.
    Properties
    Immunogen
    Synthetic peptide within Human Integrin beta 1 aa 738-798. The exact sequence is proprietary.
    Clonality
    Monoclonal, clone number: 5BF7
    Isotype
    Rabbit IgG
    Form
    Liquid, 100 μl,1mg/ml, PBS (pH 7.2) and 40% Glycerol,0.02% Sodium Azide
    Storage instruction
    Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C, Avoid freeze / thaw cycle.
    Host
    Rabbit
    Applications
    WB Image

    Western blot shows lysates of L 929 mouse fibroblast cell line, NIH 3T3 mouse embryonic fibroblast cell line, PC 3 human prostate cancer cell line, Rat 2 rat embryonic fibroblast cell line, and RAW 264.7 mouse monocyte/macrophage cell line. PVDF membrane was probed with 1:1000 of Anti-Integrin beta 1/CD29 Antigen Affinity-purified Polyclonal Antibody (Catalog: AT0708) followed by HRP-conjugated Anti-Rabbit IgG Secondary Antibody (Catalog: AT0097) 
    A specific band was detected for Integrin beta 1/CD29 at approximately 110-140 kDa (as indicated). This experiment was conducted under reducing conditions
     

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