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    Anti-VDAC1/Porin Mouse mAb - Mitochondrial Loading Control

    Catalog number :AT0427
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    VDAC1 is an outer membrane mitochondrial protein. The VDAC proteins are thought to form aqueous channels, or pores, through which adenine nucleotides cross the outer mitochondrial membrane. VDACs have been implicated in the formation of the mitochondrial permeability transition pore complex in apoptotic cells. This complex, formed by VDAC, adenine nucleotide translocator (ANT), and cyclophilin D (CypD), is thought to allow the mitochondria to undergo metabolic uncoupling and irreversible morphologic changes that ultimately destroy the mitochondria during apoptosis. VDACs are highly expressed in heart, liver and skeletal muscle, where concentrations of mitochondria are at their highest.
    Overview
    Reactivity
    Mouse, Rat, Human
    Tested applications
    WB (1:500-1:1000)
    Optimal dilutions/concentrations should be determined by the end user. 
    Specificity
    VDAC1 Antibody detects endogenous levels of VDAC1
    Properties
    Immunogen
    VDAC1/Porin fusion protein (Genbank No: BC008482).
    Clonality
    8A7
    Isotype
    Mouse IgG2a
    Form
    Liquid, 100 μl,1mg/ml
    Storage instruction
    Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C 
    Host
    Mouse
    Applications
    WB Image

    Western blot analysis of Hela cell lysates
    Predicted band size: 31 kDa
    Observed Size: 31 kDa
    Anti- VDAC1 antibody at 1:1000

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