Anti-VDAC1/Porin Mouse mAb - Mitochondrial Loading Control
Catalog number :AT0427
VDAC1 is an outer membrane mitochondrial protein. The VDAC proteins are thought to form aqueous channels, or pores, through which adenine nucleotides cross the outer mitochondrial membrane. VDACs have been implicated in the formation of the mitochondrial permeability transition pore complex in apoptotic cells. This complex, formed by VDAC, adenine nucleotide translocator (ANT), and cyclophilin D (CypD), is thought to allow the mitochondria to undergo metabolic uncoupling and irreversible morphologic changes that ultimately destroy the mitochondria during apoptosis. VDACs are highly expressed in heart, liver and skeletal muscle, where concentrations of mitochondria are at their highest.
- Overview
- Reactivity
- Mouse, Rat, Human
- Tested applications
- WB (1:500-1:1000)Optimal dilutions/concentrations should be determined by the end user.
- Specificity
- VDAC1 Antibody detects endogenous levels of VDAC1
- Properties
- Immunogen
- VDAC1/Porin fusion protein (Genbank No: BC008482).
- Clonality
- 8A7
- Isotype
- Mouse IgG2a
- Form
- Liquid, 100 μl,1mg/ml
- Storage instruction
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C
- Host
- Mouse
- Applications
- WB Image
Western blot analysis of Hela cell lysatesPredicted band size: 31 kDaObserved Size: 31 kDaAnti- VDAC1 antibody at 1:1000
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