anti-Human CD3 antibody (In Vivo Grade) for T cell Activation

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anti-Human CD3 antibody (In Vivo Grade) for T cell Activation

Catalog number :AT6003

This monoclonal antibody reacts with human CD3ε, a 20 kDa transmembrane cell-surface protein that belongs to the immunoglobulin superfamily. CD3ε is one of five polypeptide chains that combine to form the TCR complex. CD3ε is expressed on T lymphocytes, NK-T cells, and to varying degrees on developing thymocytes. CD3 plays roles in TCR signaling, T lymphocyte activation, and antigen recognition. This antibody has immunosuppressive properties in vivo and has been shown to effectively treat renal, heart and liver allograft rejection.

Overview

Description: anti-Human CD3 antibody (In Vivo Grade) for T cell Activation In vitro

Tested applications: in vitro T cell stimulation/activation

in vivo T cell depletion in humanized mice

ex vivo T cell inhibition for xenografts

Flow cytometry

Attention: using dilution buffer (pH 7.0, 0.2 μm filtered)

Properties

Immunogen: Human T lymphocytes

Isotype: Mouse IgG2a, κ

Form: 0.2 μm filtered,

Endotoxin <2EU/mg (<0.002EU/μg)

Determined by LAL gel clotting assay

Storage instruction: This antibody solution should be stored at the stock concentration at 4°C. Do not freeze.

Storage buffer: PBS, pH 7.0 Contains no stabilizers or preservatives

Purity: Purified by Protein G beads from tissue culture supernatant in an animal free facility

>95%

Determined by SDS-PAGE

anti-Human CD3 antibody (In Vivo Grade) for T cell Activation

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