This monoclonal antibody reacts with mouse CD28, a 45 kDa costimulatory receptor and a member of the Ig superfamily. CD28 is expressed by thymocytes, most peripheral T cells, and NK cells. CD28 is a receptor for CD80 (B7-1) and CD86 (B7-2). Signaling through CD28 augments IL-2 and IL-2 receptor expression as well as cytotoxicity of CD3-activated T cells. This antibody has been shown to stimulate the proliferation and cytokine production by activated T and NK cells and provide a costimulatory signal for CTL induction.
anti-Mouse CD28 antibody (In Vivo Grade) for T cell Activation
Catalog number :AT6002
- Overview
- Description
- anti-Mouse CD28 antibody (In Vivo Grade) for T cell Activation In vitro and Blocking CD28 In Vivo
- Tested applications
- In vitro mouse T cell stimulation/activationIn vivo mouse CD28 blockadeAttention: using dilution buffer (pH 6.0, 0.2 μm filtered)
- Properties
- Immunogen
- Mouse T cell lymphoma EL-4 cells
- Isotype
- Syrian Hamster IgG2
- Form
- 0.2 μm filtered,Endotoxin <2EU/mg (<0.002EU/μg)Determined by LAL gel clotting assay
- Storage instruction
- This antibody solution should be stored at the stock concentration at 4°C. Do not freeze.
- Storage buffer
- PBS, pH 6.0 Contains no stabilizers or preservatives
- Purity
- Purified by Protein G beads from tissue culture supernatant in an animal free facility>95%Determined by SDS-PAGE
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