anti-Mouse CD3 antibody (In Vivo Grade) for T cell Activation
Catalog number :AT6004
This monoclonal antibody reacts with mouse CD3, a transmembrane cell-surface protein that belongs to the immunoglobulin superfamily. CD3 associates with TCR α/β or γ/δ chains to form the TCR complex. CD3 is expressed on T lymphocytes, NK-T cells, and to varying degrees on developing thymocytes. CD3 plays roles in TCR signaling, T lymphocyte activation, and antigen recognition. This antibody has been shown to block the binding of the antibody suggesting that this antibody recognizes an epitope of the CD3ε chain. Treatment with this antibody in vivo has been tested to partially deplete T lymphocytes and temporarily down-modulate CD3 expression on T cells.
- Overview
- Description
- anti-Mouse CD3 antibody (In Vivo Grade) for T cell Activation
- Tested applications
- in vitro T cell stimulation/activation
Attention: using dilution buffer (pH 7.0, 0.2 μm filtered)
- Properties
- Immunogen
- γδ TCR-positive T-T hybridoma D1
- Isotype
- Rat IgG2b, κ
- Form
- Liquid, 0.2 μm filtered,Endotoxin <2EU/mg (<0.002EU/μg)Determined by LAL gel clotting assay
- Storage instruction
- This antibody solution should be stored at the stock concentration at 4°C. Do not freeze.
- Storage buffer
- PBS, pH 7.0 Contains no stabilizers or preservatives
- Purity
- Purified by Protein G beads from tissue culture supernatant in an animal free facility>95%Determined by SDS-PAGE
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