Anti-beta Amyloid Rabbit mAb

Product

Anti-beta Amyloid Rabbit mAb

Catalog number :AT0689

Amyloid β (Aβ) precursor protein (APP) is a 100-140 kDa transmembrane glycoprotein that exists as several isoforms. The amino acid sequence of APP contains the amyloid domain, which can be released by a two-step proteolytic cleavage. The extracellular deposition and accumulation of the released Aβ fragments form the main components of amyloid plaques in Alzheimer's disease. APP can be phosphorylated at several sites, which may affect the proteolytic processing and secretion of this protein. Phosphorylation at Thr668 (a position corresponding to the APP695 isoform) by cyclin-dependent kinase is cell-cycle dependent and peaks during G2/M phase. APP phosphorylated at Thr668 exists in adult rat brain and correlates with cultured neuronal differentiation.

Overview

Reactivity: Human, Mouse, Rat, Monkey

Tested applications: Western Blotting 1:1000

Immunoprecipitation 1:200

Immunohistochemistry (Paraffin) 1:500

Optimal dilutions/concentrations should be determined by the end user.

Specificity: This antibody detects endogenous levels of total beta Amyloid protein.

Properties

Immunogen: Synthetic peptide, corresponding to amino acids 1-17 of Human beta Amyloid.

Clonality: Monoclonal, clone number: 4H21

Isotype: Rabbit IgG

Form: Liquid, 100 μl,1mg/ml, PBS (pH 7.2) and 40% Glycerol，0.02% Sodium Azide

Storage instruction: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C, Avoid freeze / thaw cycle.

Host: Rabbit

Applications

WB Image: Western Blot: beta Amyloid Antibody - human (A), mouse (B), and rat (C) brain tissue lysates with APP antibody at 1;1000

IHC Image: Immunohistochemistry: beta Amyloid Antibody- Analysis of APP in human brain tissue with APP antibody at 1:500.

ICC/IF Image: Immunofluorescence: beta Amyloid Antibody - Rat heart tissue with antibody at 1:500.

Anti-beta Amyloid Rabbit mAb

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