Anti-c-Abl Rabbit mAb

Product

Anti-c-Abl Rabbit mAb

Catalog number :AT0365

Protein kinase that regulates key processes linked to cell growth and survival. Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.

Overview

Description: Rabbit monoclonal antibody to c Abl, This antibody detects endogenous levels of total c-Abl protein.

Reactivity: Mouse, Human, Rat

Tested applications: WB 1:1000
IHC 1:500

Properties

Immunogen: The antiserum was produced against synthesized non-phosphopeptide derived from human c-Abl around the phosphorylation site of tyrosine 412 (D-T-Y^P-T-A).

Clonality: Monoclonal, clone number: 5G7

Isotype: IgG

Form: Liquid
Preservative: 0.02% Sodium Azide
Constituents: 50% Glycerol, PBS, 150mM Sodium chloride, pH 7.4

Storage instruction: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Database links

Applications

IHC Image: Immunohistochemistry (Paraffin-embedded sections) - c Abl antibody
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue in the presence (right) and absence (left) of blocking peptide, using AT0365 at 1/50 dilution.

Anti-c-Abl Rabbit mAb

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