VHH are single-domain antibodies derived from the variable regions of heavy chain of Alpaca immunoglobulin. The size of VHH is extremely small (<15 kDa) compared to other forms of antibody fragment, which significantly increase the permeability of VHH. Thus, VHH is considered of great value for research, diagnostics and therapeutics.
Alpaca-CoIP-MOU™ Anti-Mouse IgG Alpaca Nanobody (HRP) for IP/CoIP is designed for detecting NATIVE Fc region of mouse IgG(H+L) specifically. It is based on monovalent, recombinant single domain antibodies to mouse IgG(H+L) coupled to HRP. Based on western blot and/or ELISA, it reacts with NATIVE mouse IgG(H+L) selectively, no reactivity with rabbit, human, cynomolgus, rat, goat IgG.
Alpaca-CoIP-MOU™ Anti-Mouse IgG Alpaca Nanobody (HRP) for IP/CoIP is western blotting reagents that enable the trouble-free detection of western blotted target protein bands from upstream IP/CoIP, without interference from denatured IgG (IP primary antibody). This allows to detect the (co-)immunoprecipitated protein without interfering by the IgG heavy (50 kDa) and light chains (25 kDa). In general, this interference tends to originate from traditional secondary antibodies which recognize primary antibodies released with the antigen during the immunoprecipitation procedure or endogenous IgGs from the lysate itself.
Alpaca-CoIP-MOU™ Anti-Mouse IgG Alpaca Nanobody (HRP) for IP/CoIP only recognize native (non-reduced) primary antibodies (from mouse) and therefore the bands of heavy and light chains is highly minimized, if the immunoprecipitated antigen-antibody complex is fully reduced and denatured before downstream WB.
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All our products are For Research Use Only. Not for diagnostic or therapeutic usages.