Anti-Caspase 8 Rabbit mAb
Catalog number :AT0379
Apoptosis induced through the CD95 receptor (Fas/APO-1) and tumor necrosis factor receptor 1 (TNFR1) activates caspase-8 and leads to the release of the caspase-8 active fragments, p18 and p10. Activated caspase-8 cleaves and activates downstream effector caspases such as caspase-1, -3, -6, and -7. Caspase-3 ultimately elicits the morphological hallmarks of apoptosis, including DNA fragmentation and cell shrinkage.
- Overview
- Description
- Rabbit monoclonal antibody to Caspase-8
- Reactivity
- Human, Mouse, Rat
- Tested applications
IHC-P : Use at an assay dependent concentration. ICC/IF : Use at an assay dependent concentration. WB : Use a concentration of 1/500. Detects a band of approximately 18kDa and 55kDa .
- Properties
- Immunogen
- Recombinant fragment corresponding to Human Caspase-8 p18 (C terminal).
- Clonality
- Monoclonal, clone number: 3C3
- Isotype
- Rabbit IgG
- Form
- Liquid
Preservative: 0.02% Sodium Azide
Constituents: 1% BSA, PBS, pH 7.4Liquid
- Storage instruction
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
- Applications
- Application Image
Western blot - Anti-Caspase-8 p18 antibodyLane 1 : Anti-Caspase-8 p18 antibody at 1/250 dilutionLane 2 : Anti-Caspase-8 p18 antibody at 1/500 dilutionLane 1 : Extract from Human Jurkat cellsLane 2 : Extract from Human Jurkat cellsPredicted band size : 55 kDa and 18 kDa
Related Products
| Catalog number | AT0377 |
| Catalog number | AT0550 |
Reviews
loading...
Payments by 
All our products are For Research Use Only. Not for diagnostic or therapeutic usages.