95% of the human genome does not actually encode proteins, but produces a large number of non coding RNAs (ncRNAs). These RNAs play an important role in the growth and development of life, are closely related to AIDS virus/AIDS, leukemia, diabetes and other diseases, and participate in the regulation of stem cell development and epigenetics. RNA protein complexes drive post transcriptional regulation of gene expression in almost all cellular processes, including splicing, nuclear output, mRNA stability, and protein translation. Therefore, the understanding of post transcriptional regulatory networks and mechanisms depends on identifying changes in RNA binding during these processes.
RNA binding proteins control many aspects of cell biology by binding to single stranded RNA binding motifs (RBMs). However, RBM can be hidden within its local RNA structure, thereby inhibiting RNA protein interactions.
The study of the interaction between RNA and protein is receiving increasing attention from scientists and has become a hot topic in epigenetic research.
The magnetic bead RNA protein pull down capture kit provides researchers with a simplified and efficient method of using end biotin labeled RNA as bait to enrich proteins interacting with RNA. Applicable to the interaction between RBP and mRNA, RBP and LncRNA, RBP and miRNA, and RBP and circRNA. Western blot validation and mass spectrometry identification of known proteins downstream.
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